IRSN, Institut de radioprotection et de sûreté nucléaire

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Enhancing Nuclear Safety


Research units

Radiobiology of Accidental Exposure Laboratory (LRAcc)

The Radiobiology of Accidental Exposure Laboratory (LRAcc) is located at Fontenay-aux-Roses, in the Paris region and managed by Gaëtan Gruel. In 2008, the laboratory obtained accreditation from COFRAC for its cytogenetic analysis activity.

Biological dosimetry is the assessment of the impairment of an irradiated person based on the radiation-induced variations of certain biological parameters. Biological dosimetry is complementary to clinical symptomatology and physical dosimetry.





Context and research themes


The Radiobiology of Accidental Exposure Laboratory (LRAcc) is in the field of main research thematique "Biological doimetry and indicators".



Research axes


  • Set up an operational organization and means enabling assessments to be performed by biological dosimetry in case of a radiological or nuclear accident;
  • Perform biological dosimetry assessments, within the above mentioned organization or as a service, for proven or suspected radiation overdoses in the case of a radiological or nuclear accident, or in the medical sector and professional sector (workers, patients), in agreement with the policy defined by the Institute;
  • Study the operational application of new biological dosimetry methods to reconstitute the dose received by a person exposed to ionizing radiation of any type (external, internal, heterogeneous, localized, past);
  • Participate in the research carried out within the radiology and epidemiology service on biological diagnostic and prognostic indicators making it possible to better estimate radiation induced damage, and to study their operational application.



Research team


Gaëtan Gruel, head of laboratory

Céline Baldeyron, researcher and deputy head of laboratory

Morgane Dos Santos, researcher

Delphine Dugué, technician

Stéphane Flamant, researcher

Géraldine Gonon, researcher

Éric Grégoire, researcher

Bruno L'Homme, technician

Céline Loinard, researcher

Cécile Martin-Bodiot, technician

Juan Martinez Guerrero, researcher

Aurélie Vaurijoux, research engineer

Pascale Voisin, technician

Laure Bobyk, post-doc student (2017-2018)

Amélie Fréneau, PhD student (2015-2018)

Alexandre Ribault, PhD student (2015-2018)


Facilities and techniques


  • Conventional and fluorescence microscopes
  • An image analysis system developed by a French company specializing in medical imagery and validated by the LRAcc with regard to the biological dosimetry part
  • Two flow cytometers, including a cell analyzer-sorter
  • An automatic detection system for chromosomal anomalies
  • A confocal microscope
  • Culture rooms with laminar flow extractors

Send Print
Remplissage de tubes avec le mélange fixateur pour fixation des chromosomes.  Crédits : Olivier Seignette/Mikaël Lafontan/IRSN



Gaëtan Gruel, head of laboratory



Radiobiology of Accidental Exposure Laboratory (LRAcc)
BP 17
92262 Fontenay-aux-Roses Cedex


By Phone : +33 (0)1 58 35 98 98


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