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Enhancing Nuclear Safety


Research

Research units

Radiobiology of Accidental Exposure Laboratory (LRAcc)


September 2017

 

The LRAcc, located in Fontenay-aux-Roses, carries out research in the fields of Radiobiology, Biological Dosimetry, Radiopathology and Regenerative Medicine in the context of accidental exposure to ionizing radiation (as a result of radiological, industrial, medical and nuclear accidents, as well as malicious acts), with a view to developing IRSN's assessment capabilities and thus improve medical treatment for victims.

 

 

 

 

Background and areas of research

 

Through its research, the LRAcc develops operational methods and tools used for the diagnosis and prognosis of radiation-induced organ damage. Among other things, this entails using biological dosimetry in the a posteriori reconstitution of absorbed doses. The laboratory also provides scientific and technical support for implementing medical treatment strategies adapted to various dose levels liable to cause pathologies that compromise the patient's short-, medium- and/or long- term chances of survival.

 

 

Research priorities

 

Research carried out at LRAcc aims to improve dose assessment, risk prediction, and the treatment solutions available:

 

  • By studying the effects of different exposure scenarios (dose and dose rate, nature and energy of the radiation) on the molecular components of cells (including DNA) and their consequences at cell level;
  • By proposing new dose assessment and diagnosis tools based on radiation-induced damage;
  • By developing new models for predicting related risks, depending on known or supposed accidental exposure paramaters; 
  • By identifying and performing experiments to validate new treatment targets for the medical treatment of severe radiation-induced lesions, including cell therapy;
  • By studying the mechanisms involved in the action of such new treatments, to make them more effective and ensure that they are harmless, and support their transfer to clinical use.

 

 

Research activities carried out at the laboratory are geared to implementing and improving its assessment activities, in order to:

 

  • Develop the operational organization and resources required to respond in situations calling for an assessment of received doses and scientific and technical support for treating persons exposed to ionizing radiation in the event of a radiological accident (in the industrial, medical or nuclear sector) or as a result of a malicious act;
  • Be involved in the post-accident monitoring of casualties, within the framework of agreements signed with the key agencies in France and worldwide;
  • Perform biological dosimetry assessments in line with IRSN's policy;
  • Respond or contribute, in its field of expertise, to requests for advice or assessment made by the French authorities and other international bodies;
  • Be part of IRSN's emergency response management teams;

 

 

Research team

 

Gaëtan Gruel, Researcher and Director of the LRAcc
Céline Baldeyron, Researcher and Assistant Director of the LRAcc
Morgane Dos Santos, Researcher
Stéphane Flamant, Researcher
Géraldine Gonon, Researcher
Éric Grégoire, Researcher
Céline Loinard, Researcher
Juan Martinez Guerrero, Researcher
Aurélie Vaurijoux, Researcher
Delphine Dugué, Technician
Cécile Martin-Bodiot, Technician
Bruno L'Homme, Technician
Pascale Voisin, Technician
Laure Bobyk, Post-doctoral researcher (2017-2018)
Amélie Fréneau, Doctoral researcher (2015-2018)
Alexandre Ribault, Doctoral researcher (2015-2018)

 

 

Equipment and methods

 

To carry out its research and assessment programs, the LRAcc is equipped with:

 

  • a series of eight automated microscopes coupled to image analysis systems, used to measure a variety of biological parameters (conventional cytogenetics, FISH, high-speed imaging, etc.)
  • a genomics platform
  • a cell culture room for producing human blood cell cultures (Level 2 containment laboratory).

 

 

Partnerships and research networks

 

International networks:   

 

  • RENEB (Realizing the European Network of Biodosimetry)
  • Eurados (European Radiation Dosimetry Group)
  • RANET (Response and Assistance Network)

 

International collaboration

 

  • CPHR (Center for Radiation Protection and Hygiene) in Cuba

 

National collaboration

 

  • The AIFIRA ion beam facility (Applications Interdisciplinaires de Faisceaux d'Ions en Région Aquitaine) at the CENBG nuclear research center (Centre d'Etudes Nucléaires de Bordeaux-Gradignan)
  • The CEA (Commissariat à l'énergie atomique et aux énergies alternatives - the French Alternative Energies and Atomic Energy Commission)
  • IRBA (Institut de recherche biomédicale des armées - the French Armed Forces Biomedical Research Institute) 

 

 


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Contact

​Gaëtan Gruel, head of laboratory


IRSN/PSE-SANTÉ/SERAMED

Radiobiology of Accidental Exposure Laboratory (LRAcc)
BP 17
92262 Fontenay-aux-Roses Cedex
France

 

By Phone : +33 (0)1 58 35 98 98

Equipment and facilities

​Shielded X-ray radiation platform (SARRP-Xstrahl)

Linear accelerator for medical use (ALPHEE)

Ion microbeam radiation platform (MIRCOM= Microfaisceau d’Ions dédié à la Radiobiologie des COMmunications intra et intercellulaires)


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