SharePoint
Aide
IRSN, Institut de radioprotection et de sûreté nucléaire

Search our site :

ok

Contact us :

ok
En Fr

Enhancing Nuclear Safety


Research

Publications

Implication of neurogenesis during brain development in behavior disorders caused by depleted uranium

​Marie Legrand has defended her thesis on 31st March 2016 at IRSN in Fontenay-aux-Roses (France).

Document type > *Mémoire/HDR/Thesis

Keywords >

Research Unit > IRSN/PRP-HOM/SRBE/LRTOX

Authors > LEGRAND Marie

Publication Date > 31/03/2016

Summary

Humans are continuously exposed to neurotoxic compounds in the environment. The developing brain is more susceptible to neurotoxic compounds and modifications in its growth could lead to disorders in adulthood. Uranium (U) is an environmental heavy metal and induces behavioral disorders aswell as affects neurochemistry. The aim of my thesis was to investigate whether depleted uranium (DU) exposure affects neurogenesis processes, which are implicated in brain development and in synaptic plasticity in adults. While DU increased cell proliferation in the hippocampal neuroepithelium and decreased cell death at prenatal stages, DU lead to opposite effects in the dentate gyrus at postnatal stages. Moreover, DU had an inhibitory effect on the transition toward neuronal differentiation pathway during development. At adult stage, DU induced a decrease in neuronal differentiation but has no impact in cell proliferation. Finally, DU exposure during brain development caused depressive like behavior at late postnatal and adult stage, and decreased spatialmemory at adult stage. Consequently, DU exposure during brain development caused modification in neurogenesis processes associated to cognitive and emotional disorders at adult age. U could present a threat to human health, especially in pregnant women and children.

Close

Send to a friend

The information you provide in this page are single use only and will not be saved.
* Required fields

Recipient's email:*  

Sign with your name:* 

Type your email address:*   

Add a message :

Do you want to receive a copy of this email?

Send

Cancel

Close

WP_IMPRIMER_TITLE

WP_IMPRIMER_MESSAGE

Back

Ok