This contribution presents a study on the consequences of applying ventilation procedures during a fire scenario involving a TPH/TBP pool fire in a ventilated enclosure. This research is addressed to fire safety in the nuclear industry in which ventilated enclosures remain a configuration frequently encountered. This work presents experiments comprising a 300 kW liquid pool fire in a 400 m3 vessel connected to an industrial ventilation system featuring one inlet and one exhaust branch. The investigated ventilation procedures consist in closing the inlet branch only or closing both inlet and exhaust branches. The analysis compares fire behaviour with and without the implementation of a ventilation procedure and points out the effects of said procedures on the combustion rate, fire duration and gas temperature within the vessel. It highlights pressure variations within the vessel when both the inlet and exhaust ventilation branches are closed. Conclusions provide practical answers that would be useful when designing appropriate ventilation strategies limiting fire hazards.