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IRSN, Institut de radioprotection et de sûreté nucléaire

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Enhancing Nuclear Safety


Research

Publications

Progress and trends in in vivo chelation of uranium

AUTHORS : Henge-Napoli, M.H.; Ansoborlo, E.; Houpert, P.; Mirto, H.; Paquet, F.; Burgada, R.; Hodgson, S.; Stradling, G.N Radiation Prot. Dos. 1998, vol 79 n° 1-4, 449-452 WORKSHOP ON INTAKES OF RADIONUCLIDES: Occupational and Public Exposure - Proceedings of a Workshop held in Avignon, France. September 15-18 1997

Summary

Accidental internal contamination of humans by uranium can induce radiological or chemical toxicity, their relative importance beeing dependant on the isotopic composition. The current approach for reducing the risk of biological effects is to administer chelating agents that will enhance the excretion of uranium. The results obtained with several phosporus bearing compounds including phosphonic acids, diphosphonates and phosphoalkylphosphates and with 3,4,3-LIHOPO, an effective agent for other actinides, are presented here. The development of new approaches designed to optimise the decorporation of uranium carried out under the Europen Union 4th Framework Program is described.

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