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Synthesis of 3,4,3 LI 1,2 HOPO labelled with C-14.

Burgada R., Bailly T., Noel J.P., Gomis J.S., Valleix A., Ansoborlo E., Henge-Napoli M.H., Paquet F., and Gourmelon P. Journal of Labelled compounds and radiopharmaceuticals 44(1), 13-19

Summary

3,4,3LI 1,2 HOPO 1 or LIHOPO (1,5,10,14-tetra (l-hydroxy-2-pyridone-6-oyl)-l,5,10,14-tetraazatetradecane) is a decorporation agent used against actinides. It was synthesised labelled with carbon 14 with a view to metabolism studies. [6,9-14C]-LIHOPO 2 was obtained in two radioactive steps through a very convenient synthesis in 50 % radioactive yield from commercially available [1,4-14C]-spermine, hydrochloride and 1-benzyloxy-6-oxo-l,6-dihydro-pyridine-2-carbonyl chloride 7. The synthesis of 7 is also described.

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