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Les neuropeptides gastro-intestinaux cibles des effets des rayonnements ionisants: alterations fonctionnelles

Linard, C.; Esposito, V.; Wysocki, J.; Griffiths, N.M. Journal de Chimie Physique et de Physico-Chimie Biologique, (Apr 1998) (no.4t.95) p. 816-819

Document type > *Article de revue

Keywords > digestive radiobiology, neuropeptides

Research Unit > LRPAR_(Radiopathology research laboratory)

Authors > LINARD Christine

Publication Date > 01/04/1998

Summary

The symptoms associated with exposure to ionizing radiation are nausea, vomiting, diarrhea. The response of the gut is complex involving modifications of motility and fluid and electrolyte transport. Gastrointestinal regulatory peptides have an important role in these functions. This study showed that radiation-induced tissue variations of neuropeptides have some repercussions on intestinal biological activity of these peptides soon after irradiation. In addition such modifications are also seen a few years after irradiation.

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