SharePoint
Aide
IRSN, Institut de radioprotection et de sûreté nucléaire

Search our site :

ok

Contact us :

ok
En Fr

Enhancing Nuclear Safety


Research

Publications

Phenotypic and immunohistological analyses of the human adult thymus: evidence for an active thymus during adult life

Bertho JM, Demarquay C, Moulian N, Van Der Meeren A, Berrih-Aknin S, Gourmelon P Cell Immunol 1997 Jul 10;179(1):30-40

Document type > *Article de revue

Keywords > radiohematology, thymus

Research Unit > LRTI_(Therapeutic irradiation research laboratory)

Authors > BERTHO Jean-Marc, DEMARQUAY Christelle, GOURMELON Patrick

Publication Date > 01/07/1997

Summary

We analyzed cellular content of thymic samples from 26 human healthy donors, ranging from 1 week postnatal to 49 years old. Our results showed that there was an overall decrease in cellular density, beginning early during life, but with two peaks of cellular density, at 9 months and 10 years of age. Histological and immunohistological analyses showed that variations in cellular density were correlated with the morphological changes observed during thymic involution, namely the enlargement of interlobular trabeculae and the development of adipocytic tissue. However, the adult thymus still contained thymocytes, up to 49 years. Phenotypic analysis showed no significant variations according to the age of donors in the distribution of the main thymocyte subsets, both precursors and more mature cells. These results suggest that the human thymus remains active during adult life.

Close

Send to a friend

The information you provide in this page are single use only and will not be saved.
* Required fields

Recipient's email:*  

Sign with your name:* 

Type your email address:*   

Add a message :

Do you want to receive a copy of this email?

Send

Cancel

Close

WP_IMPRIMER_TITLE

WP_IMPRIMER_MESSAGE

Back

Ok