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Enhancing Nuclear Safety


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Treatment of radiation burns with surgery and cell therapy. A report of two cases


Journal title : Bulletin de l'Académie Nationale de Médecine
Volume : 191
Issue : 6
Pagination : 971-978
Publication date : 01/06/2007

Document type > *Article de revue

Keywords >

Research Unit > IRSN/DRPH

Authors > BEY Eric, CARSIN Hervé, DE REVEL Thierry, DUHAMEL Patrick, GOURMELON Patrick, LATAILLADE Jean-Jacques

Publication Date > 01/06/2007

Summary

Treatment of severe radiation burns remains a difficult challenge. Conventional surgical treatment (excision, skin grafting, skin or muscle flaps) often fails to prevent unpredictable and uncontrolled extension of the necrotic process. We report two clinical cases in which surgery was combined with mesenchymal stem cell (MSC) therapy. Clinical outcome was good and there was no recurrence of radiation inflammatory waves observed in the first patient after one year. This novel multi-disciplinary therapeutic approach, combining physical techniques, modern plastic surgery and cell therapy should improve the medical management of severe localized radiation burns.
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