SharePoint
Aide
IRSN, Institut de radioprotection et de sûreté nucléaire

Search our site :

ok

Contact us :

ok
En Fr

Enhancing Nuclear Safety


Research

Publications

Abdominal irradiation : a model of severe trauma and inflammation.

P. Monti, A. Vandermeeren, J. Wysocki, N. Griffiths, 6Th word congress on trauma shock, inflammation and sepsis pathophysiocology, immune consequences, 2-6 mars 2004, Munich, Allemagne.

Document type > *Congrès/colloque

Keywords > radio-induced inflammation

Research Unit > IRSN/DRPH/SRBE/LTCRA

Authors > MONTI Pascale

Publication Date > 02/03/2004

Summary

Ionising radiation overexposure is a possibility fatal event and high doses to the gut may in part direct the outcome. A letal dose (15 Gy) of total abdominal irradiation (TAI) to mice results in 50% survival that was ameliorated by anti-inflammatory treatment. Marked morthological changes to the intestine were observed concomitant with augmented permeabilityand decreased enzyme activities. Inflammatory mediators were increased in the intestine as well as in the lungs that were outside the radiation field. Intestienal elements were measured in mesenteric lymph nodes indicative of some trafficking by lymphatics. Thus TAI may provide a relevant model of severe trauma to study multi-organ effects.
Send Print

More information

Contact


Close

Send to a friend

The information you provide in this page are single use only and will not be saved.
* Required fields

Recipient's email:*  

Sign with your name:* 

Type your email address:*   

Add a message :

Do you want to receive a copy of this email?

Send

Cancel

Close

WP_IMPRIMER_TITLE

WP_IMPRIMER_MESSAGE

Back

Ok