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IRSN, Institut de radioprotection et de sûreté nucléaire

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Correlation between plasma FLT3-Ligand concentration and hematopoiesis during G-CSF-induced CD34+ Cell mobilization


Journal title : Stem cells and development
Volume : 17
Issue : 6
Pagination : 1221-1225
Publication date : 01/12/2008

Document type > *Article de revue

Keywords >

Research Unit > IRSN/DRPH/SRBE/LTCRA

Authors > BERTHO Jean-Marc, DEMARQUAY Christelle, DUDOIGNON Nicolas, PRAT Marie, SIMON Erwan, STEFANI Johanna, THIERRY Dominique

Publication Date > 01/12/2008

Summary

This study aimed to correlate blood Flt3-ligand (FL) concentration with CD34+ cell number in blood and bone marrow (BM) during granulocyte colony-stimulating factor (G-CSF) mobilization. Nonhuman primates were injected with 10 μg/kg of G-CSF (Lenograstim) daily over a period of 5 days. Daily blood sampling and repeated BM sampling showed that FL concentration before mobilization was negatively correlated to the absolute number of BM CD34+ cells, but also to the number of G-CSF-mobilized CD34+ cells on days 3-5 of treatment. This showed that FL concentration in the blood reflected BM status before mobilization, and suggested that this parameter could be used as a predictive indicator of G-CSF-induced CD34+ cell mobilization.

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