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IRSN, Institut de radioprotection et de sûreté nucléaire

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Enhancing Nuclear Safety


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Immunosuppressive effects of mesenchymal stem cells: Involvement of HLA-G


Journal title : Transplantation
Volume : 84
Issue : 2
Pagination : 231-237
Publication date : 01/07/2007

Summary

Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties. They are able to suppress allogenic T-cell response and modify maturation of antigen-presenting cells. Their role in the treatment of severe graft versus host disease has been reported. The underlying molecular mechanisms of immunosuppression are currently being investigated. Histocompatibility locus antigen (HLA)-G is a nonclassical major histocompatibility complex class I antigen with strong immune-inhibitory properties.

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