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Enhancing Nuclear Safety


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Le syndrome hématopoïétique induit par une irradiation accidentelle : évaluation et traitements possibles


Journal title : Radioprotection
Volume : 41
Issue : 2
Pagination : 215-227
Publication date : 01/06/2006

Summary

The hematopoietic syndrome induced by an accidental radiation: evaluation and treatments. The accidental radiation-induced hematopoietic syndrome remains difficult to treat, mainly due to the heterogeneity of irradiation. As a result, there always remains an area of active hematopoiesis that was partly protected from irradiation. The choice of a therapeutic strategy must be based upon the estimate of radiation damage to the bone marrow. This can be achieved by the use of biological indicators of radiation dose or damage such as the follow up of Flt3 ligand concentration in the blood. The possible therapeutic strategies remain limited, either stem cell transplantation or supportive care. A new approach based upon autologous cell therapy was proposed and the results highlighted new insight about the radiation-induced multiple organ disease syndrome. Other recent results from our lab suggested that among the possible therapeutic strategies, the stimulation of residual hematopoesis by the mean of cytokines such as G-CSF is one of the most interesting strategies. These new data highlight the notion of residual hematopoiesis but also the fact that regulation mechanisms of residual hematopoiesis are not well understood.


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