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Enhancing Nuclear Safety


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New biological indicators to evaluate and monitor radiation-induced damage: an accident case report


Journal title : Radiation Research
Volume : 169
Issue : 5
Pagination : 543-550
Publication date : 01/05/2008

Summary

Purpose: To evaluate damages to the main physiological systems in a victim exposed accidentally to 4.5 Gy by the mean of several new biological indicators. Methods: Blood samples were used for biological dosimetry and for measurement of plasma concentration of several molecules: Flt3 ligand for evaluation of the hematopoietic system, citrulline as an indicator of the digestive tract and several oxysterols as markers of lipid metabolism and vascular system. Results: Cytogenetic evaluation estimated the dose received by the victim from 4.2 to 4.8 Gy, according to the methodology used. The follow-up of Flt3 ligand demonstrated the severity of bone marrow aplasia. By contrast, citrulline concentration showed the absence of gastro-intestinal damage. Variations in oxysterols concentrations suggested a radiation-induced damage to the liver and to the cardiovascular system. These results were correlated to biochemical markers classically used. Conclusion: Variations in these bio-indicators demonstrated the severe damage to the hematopoietic system, but also suggested the appearance of sub-clinical damages to the liver and the cardio-vascular system. These results demonstrate for the first time the importance of a multi-parametric approach in the evaluation of radiation damage after an accidental irradiation.

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