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Stage specific phosphoinositides turnover capacity of human intrathymic T cells following CD2-triggering

Mossalayi MD, Dalloul AH, Bertho JM, Bismuth G, Blanc C, Debre P.
Biol.Bioch Res.com.Volume 168, Issue 2, 1990, Pages 665-671

Document type > *Article de revue

Keywords > radiological protection, radiohematology, interleukin, ex vivo expansion

Research Unit > IRSN/DRPH/SRBE/LTCRA

Authors > BERTHO Jean-Marc

Publication Date > 01/02/1990

Summary

Triggering of distinct CD2 epitopes on human T lymphocytes increases their phosphatidylinositol (PI) cycle-related metabolism. In this work, we investigated the relationship between this signal transduction pathway following surface CD2 antigen triggering and intrathymic T cell development. Therefore, various thymocyte subsets were incubated with co-mitogenic CD2(I+III) mAb. The cells were then tested for their various phosphoinositides levels as well as their ability to proliferate in response to recombinant interleukin-2 (rIL-2). Our results indicate that immature CD4-CD8- cells have high PI metabolism while more mature CD4+CD8+ and unfractionated thymocytes display significantly lower PI-turnover. Mature CD4+CD8- and CD4-CD8+ thymocytes regain this transduction capacity. Thus, PI-turnover following CD2-triggering is linked to the developmental fate of thymocyte subclasses.
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