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UMINERS + ANIMAL DATA Programm - Final report Quantification of lung cancer risk after low radon exposure and low exposure rate : synthesis from epidemiological and experimental data

Final report, september 2003

Coordinateur du projet : Margot TIRMARCHE (IRSN, France)

Summary

Project's coordinator : Margot TIRMARCHE (IRSN, France)

Partners :
> IRSN, France (Partner 1): D. Laurier, A. Rogel, S. Billon, D. Bergot, G. Monchaux
> BfS, Germany (Partner 2): B. Grosche, G. Hammer, M Kreuzer, M Schnelzer, A Tschense (née Brachner)
> NRPI, Czech Republic (Partner 3): L. Tomasek
> GSF, Germany (Partner 4): I. Brueske-Hohlfeld, W. Heidenreich, C. Kaiser, A. Schaffrath-Rosario, H.E. Wichmann
> CEA, France (Partner 5): J.P. Morlier
> AEA-T, United Kingdom (Partner 6): C. Collier
> NRPB, United Kingdom (Partner 7): C. Muirhead, R. Haylock
> RIVM, The Netherlands (Partner 8): M. Brugmans, H. Bijwaard, S. Rispens, H. Leenhouts


Summary : QUANTIFICATION OF LUNG CANCER RISK AFTER LOW RADON
EXPOSURE AND LOW EXPOSURE RATE : SYNTHESIS FROM
EPIDEMIOLOGICAL AND EXPERIMENTAL DATA

Radon is a radioactive gas produced during the decay of uranium 238 that is present in soil. It was classified as a human lung carcinogen in 1988, based on evidence both from animal studies and from human studies of miners with high levels of radon exposure. Radon is present everywhere; therefore the quantification of the risk associated with exposure to it is a key public health issue.

Objectives

The project aimed to analyse the risk associated with radon inhalation at low doses and at low rates of exposure. It involved researchers from three different fields: epidemiology, animal experiments and mechanistic modelling and provided a unique opportunity to study the influence of dose-rate, mainly in the range of low daily exposures over long periods, by analysing in parallel results from both animal and epidemiological studies.

The project comprised 6 work-packages (WP). Firstly, the partners involved in epidemiology and animal experiments worked on the validation and the analysis of the data. Secondly, the data from WP1 and WP4 were transferred to the partners involved in WP5 for the application of mechanistic models. In the final step a synthesis of the results was prepared.

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