The scientific background to decorporation
D.M. Taylor, G.N. Stradling and M-H. Hengé-Napoli
Radiat. Prot. Dosim. 2000 87(1), pp 11-18
The scientific background to chelation therapy is reviewed. A review of the animal studies which have demonstrated that in animals treated with DTPA either a reduction in bone tumour incidence from internally deposited 239Pu and 241Am, or a significant increase in survival time may occur, suggests that it is reasonable to assume that could also occur in humans. The biokinetics and bioinorganic chemistry of cobalt, caesium, thorium, uranium, neptunium, plutonium and americium after their entry into the systemic circulation are reviewed briefly. These reviews discuss the general biokinetic behaviour of each element in adult humans with special reference to those aspects of their bioinorganic chemistry that either underlie existing approaches to decorporation therapy, or which might be exploitable for new types of treatment.