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Les neuropeptides gastro-intestinaux cibles des effets des rayonnements ionisants: alterations fonctionnelles


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Linard, C.; Esposito, V.; Wysocki, J.; Griffiths, N.M. Journal de Chimie Physique et de Physico-Chimie Biologique, (Apr 1998) (no.4t.95) p. 816-819

Type de document > *Article de revue

Mots clés > radiobiologie digestive, neuropeptides

Unité de recherche > Laboratoire de recherche en pathologies radio-induites_(LRPAR)

Auteurs > LINARD Christine

Date de publication > 01/04/1998

Résumé

The symptoms associated with exposure to ionizing radiation are nausea, vomiting, diarrhea. The response of the gut is complex involving modifications of motility and fluid and electrolyte transport. Gastrointestinal regulatory peptides have an important role in these functions. This study showed that radiation-induced tissue variations of neuropeptides have some repercussions on intestinal biological activity of these peptides soon after irradiation. In addition such modifications are also seen a few years after irradiation.