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Importance des communications intercellulaires en radiopathologie expérimentale: le syndrome inflammatoire radio-induit


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Agay, D.; Clarencon, D.; Multon, E.; Mestries, J.C. Van Der Meeren, A.; Mouthon, M.A.; Gourmelon, P.
Journal de Chimie Physique et de Physico-Chimie Biologique Apr 1998 (no.4 t.95) p. 654-661
Actes du colloque de radiobiologie fondamentale et appliquée : ''de la radiobiologie à la clinique'', Nice 15-20 juin 1997.

Résumé

The monolithic image of radiation pathology, the physiopathological mechanisms of which are limited to the conventional concept of specific ' target cell ' with mitotic and apoptotic cell death, is changing owing to our increasing knowledge about intercellular communications. The cellular radiation biology is currently enriched by the ' humoral ' radiation biology with its concept of ' target network ' including cells and intercellular messengers. The radiation-induced disorders observed in these networks take shape in the inflammatory reaction, which is largely involved, in the physiopathological development of the acute radiation syndrome. The concepts of a perpetual cascade of cytokines, leading to radiation-induced late effects with no biological latent period, are especially illustrated by the radiation-induced pneumonitis and pulmonary fibrosis.