Irradiation aiguë localisée: chirurgie et thérapie cellulaire. A propos de deux cas

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01/06/2007

Titre de la revue : Bulletin de l'Académie Nationale de Médecine
Volume : 191
N°: 6
Pagination : 971-978
Date de publication: 01/06/2007
Type de document > *Article de revue
Unité de recherche > IRSN/DRPH
Auteurs > BEY Eric , CARSIN Hervé , DE REVEL Thierry , DUHAMEL Patrick , GOURMELON Patrick , LATAILLADE Jean-Jacques

Treatment of severe radiation burns remains a difficult challenge. Conventional surgical treatment (excision, skin grafting, skin or muscle flaps) often fails to prevent unpredictable and uncontrolled extension of the necrotic process. We report two clinical cases in which surgery was combined with mesenchymal stem cell (MSC) therapy. Clinical outcome was good and there was no recurrence of radiation inflammatory waves observed in the first patient after one year. This novel multi-disciplinary therapeutic approach, combining physical techniques, modern plastic surgery and cell therapy should improve the medical management of severe localized radiation burns.

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