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Irradiation aiguë localisée: chirurgie et thérapie cellulaire. A propos de deux cas


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Titre de la revue : Bulletin de l'Académie Nationale de Médecine
Volume : 191
N°: 6
Pagination : 971-978
Date de publication: 01/06/2007

Type de document > *Article de revue

Mots clés >

Unité de recherche > IRSN/DRPH

Auteurs > BEY Eric, CARSIN Hervé, DE REVEL Thierry, DUHAMEL Patrick, GOURMELON Patrick, LATAILLADE Jean-Jacques

Date de publication > 01/06/2007

Résumé

Treatment of severe radiation burns remains a difficult challenge. Conventional surgical treatment (excision, skin grafting, skin or muscle flaps) often fails to prevent unpredictable and uncontrolled extension of the necrotic process. We report two clinical cases in which surgery was combined with mesenchymal stem cell (MSC) therapy. Clinical outcome was good and there was no recurrence of radiation inflammatory waves observed in the first patient after one year. This novel multi-disciplinary therapeutic approach, combining physical techniques, modern plastic surgery and cell therapy should improve the medical management of severe localized radiation burns.