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DNA double-strand break repair defects in syndromes associated with acute radiation response: at least two different assays to predict intrinsic radiosensitivity?


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Titre de la revue : International Journal of Radiation Biology Volume : 84 N° : 2 Pagination : 107-125 Date de publication : 01/02/2008

Type de document > *Article de revue

Mots clés >

Unité de recherche > IRSN/DRPH/SDE/LMDN

Auteurs > ARLETT Colin F., BENCOKOVA Zuzana, CHAVAUDRA Nicole, FAVAUDON Vincent, FORAY Nicolas, GASTALDO Jérome, JOUBERT Aurélie, ZIMMERMAN Kristin M.

Date de publication > 01/02/2008

Résumé

Purpose: Human diseases associated with acute radiation responses are rare genetic disorders with common clinical and biological features including radiosensitivity, genomic instability, chromosomal aberrations, and frequently immunodeficiency. To determine what molecular assays are predictive of cellular radiosensitivity whatever the genes mutations, the existence of a quantitative correlation between cellular radiosensitivity and unrepaired DNA double-strand breaks (DSB) repair defects was examined in a collection of 40 human fibroblasts representing 8 different syndromes.