Dosimétrie par RPE sur les ongles
Titre du congrès :12th In Vivo EPR Spectroscopy and Imaging / 9th International EPR Spin Trapping/Spin Labeling
Ville du congrès :Chicago
Date du congrès :29/04/2007
Based on the capabilities of new instrumentation and the experience gained in the use of teeth for after-the-fact dosimetry, we are undertaken a systematic EPR study of irradiated fingernails. The final goal of this work is development of accurate after-the-fact dosimetry that could be used in potentially exposed populations to determine if they have received exposure to radiation doses that could be life threatening. There have been only a modest number of previous studies of radiation-induced signals in fingernails and while there were some promising aspects, overall the results were inconsistent. Our studies include measurements of the dose and time dependences of EPR spectra in fingernails using different sample preparation procedures. Special attention is paid to the effects treatment with water on the EPR spectra of irradiated fingernails. This study is still underway but even at the present state of development, it seems quite possible that it will be feasible to use fingernails as an indicator of the severity of exposure in individuals. This may be especially effective as a complement to other techniques such as measurements of dose from teeth in situ.