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Chronic contamination with 137 Cesium in rat : effect on liver cholesterol metabolism


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Titre du congrès :XIXème International Bile Acid Meeting : Biological Actions and Clinical Relevance Ville du congrès :Fribourg Date du congrès :06/10/2006

Type de document > *Congrès/colloque

Mots clés > césium, cholestérol, foie, rat, Tchernobyl

Unité de recherche > IRSN/DRPH/SRBE/LTCRA

Auteurs > GOURMELON Patrick, GRANDCOLAS Line, GRISON Stéphane, GUEGUEN Yann, SOUIDI Maâmar, TISSANDIE Emilie, VOISIN Philippe

Date de publication > 07/10/2006

Résumé

  After the Chernobyl nuclear accident, epidemiological studies on human populations living in 137Cs-contaminated areas revealed the increase frequencies of thyroid cancer and evoked the apparition of cardiovascular diseases, hormonal effect, liver alteration, and lipid disorder. Actually, it raises a problem of public safety for the populations living on these territories that are exposed to low levels of 137Cs during a long period through food. Then it is necessary to study potential effect of this chronic contamination. To mimic this situation, the authors investigate the potential biological effects of chronic exposure to 137Cs at a postaccidental dose (150 Bq/rat/day) on hepatic metabolism of cholesterol in rat. Plasma lipid level, gene expression and activity were analyzed. It was observed that in 137Cs-exposed rats, gene expression of low-density lipoprotein receptor (LDLr), apolipoprotein B (apoB), and liver X receptor  (LXR) are increased (95%, p < .05; 34%, p < .05; 20%, p < 0.05, respectively), whereas transporter adenosine triphosphate-binding cassette transporter G5 (ABCG5) is decreased (42%, p < .05). In addition, cytochrome P450 27A1 (CYP27A1) activity is increased (34%, p < .05) in contaminated rat liver. In conclusion, the results suggest that 137Cs contamination at low-level induces molecular modifications of the liver cholesterol metabolism without leading to a dysregulation of its homeostasis. These results suggest that chronic long term exposure at low-level of 137Cs may evolve to lipid disorder.