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Down syndrome time-clustering in January 1987 in Belarus: Link with the Chernobyl accident?


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Reproductive Toxicology / Volume 24, N° 3-4, pages 289-295, 01/11/2007

Type de document > *Article de revue

Mots clés >

Unité de recherche > IRSN/DRPH/SRBE/LEPID

Auteurs > BABICHEVA Irina, GAGNIERE Bertrand, KHMEL Rostislav, LAZJUK Gennady I., ROBERT-GNANSIA Elisabeth, TIRMARCHE Margot, VERGER Pierre, ZATSEPIN Ivan

Date de publication > 01/11/2007

Résumé

The Chernobyl accident (April 26, 1986) exposed a large part of the Belarus population to ionizing radiation. We analyzed the time trends of Down syndrome (DS) in Belarus to evaluate whether either brief exposure at high dose rates during the plume passage or continuous exposure at low doses and dose rates of the residents of contaminated areas had any detectable impact on DS prevalence at birth. DS data came from the Belarus National Registry of Congenital Malformations (1981-2001). We observed a significant peak of DS in January 1987 (26 cases observed and 9.84 expected; observed/expected ratio = 2.64; 95% CI = 1.72-3.76), but found no positive long-term time trends in contaminated or control areas. The time occurrence of the January peak, high dose rates during the plume passage and experimental data showing a radiosensitive phase of oogenesis around conception time in mammals suggest that the January peak may be linked to the Chernobyl plume.