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Heterogeneous accumulation of uranium in the brain of rats


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Titre du congrès : 6th Workshop on Internal Dosimetry of Radionuclides
Ville du congrès : Montpellier
Date du congrès :02/10/2006
Titre de la revue : Radiation Protection Dosimetry 127 issue 1-4 Pages : 86-89

Type de document > *Congrès/colloque

Mots clés >

Unité de recherche > IRSN/DRPH/SRBE/LRTOX

Auteurs > BUSSY Cyril, CHAZEL Valérie, FRELON Sandrine, HOUPERT Pascale, MONLEAU Marjorie, PAQUET François

Date de publication > 01/11/2007

Résumé

Recent reports suggest that uranium can accumulate not only in known target organs, that is, kidneys or bones, but also in others such as central nervous system. In the present work, the accumulation of uranium in the brain of rats was studied after repeated exposure by inhalation, chronic exposure by ingestion and acute exposure by injection. For each route of administration, the amount of uranium entering the brain was low. The results showed different accumulation in the brain areas according to the route of intake. Injection gave a rather homogeneous distribution in the different brain areas, whereas both inhalation and ingestion yielded heterogeneous but specific accumulation. These differences in distribution suggest the operation of different mechanisms of delivery of uranium to the brain tissues.