Immunosuppressive effects of mesenchymal stem cells: Involvement of HLA-G

Titre de la revue : Transplantation Volume : 84 N° : 2 Pagination : 231-237 Date de publication : 01/07/2007

Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties. They are able to suppress allogenic T-cell response and modify maturation of antigen-presenting cells. Their role in the treatment of severe graft versus host disease has been reported. The underlying molecular mechanisms of immunosuppression are currently being investigated. Histocompatibility locus antigen (HLA)-G is a nonclassical major histocompatibility complex class I antigen with strong immune-inhibitory properties.