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Percutaneous penetration of uranium in rats after a contamination on intact or wounded skin


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Titre du congrès : 6th Workshop on Internal Dosimetry of Radionuclides
Ville du congrès : Montpellier
Date du congrès :02/10/2006
Titre de la revue : Radiation Protection Dosimetry 127 issue 1-4 Pages : 125-130

Type de document > *Congrès/colloque

Mots clés >

Unité de recherche > IRSN/DRPH/SRBE/LRTOX

Auteurs > FRELON Sandrine, GAUTIER C., MOREELS Anne-Marie, PAQUET François, PETITOT Fabrice

Date de publication > 01/11/2007

Résumé

The aim of this work is to assess in vivo in a hairless rat model, the percutaneous diffusion of uranium through intact or wounded rat skin. Six types of wounds were simulated by excoriation and burns with 10 N HF, 2, 5 and 14 N HNO3 and 10 N NaOH on anaesthetised hairless rats. Percutaneous penetration through wounded skin towards blood and subsequent urinary excretion of uranium was followed in vivo during 24 h. The influence of the physicochemical form (solution or powder) of uranyl nitrate (UN) on its percutaneous diffusion was also investigated. UN, even as a powder, can diffuse through intact skin. The presence of uranium in blood is more persistent and its urinary elimination is slower after an HF burn than after an HNO3 burn. Excoriation increases dramatically percutaneous absorption of UN. Thus, percutaneous diffusion of UN is largely dependent on skin barrier integrity with a particular importance of stratum corneum.