Review of translocations detected by fish for retrospective biological dosimetry applications
Titre de la revue : Radiation Protection Dosimetry
Volume : 113
N° : 4
Pagination : 396-402
Date de publication : 01/01/2005
Type de document >
*Article de revue
Mots clés >
Unité de recherche >
BARQUINERO Joan Francesc, BARRIOS L., CABALLIN Maria Rosa, DARROUDI Firouz, EDWARDS A., LINDHOLM Carita, LLOYD David, MOQUET J. E., ROMM Horst, ROY Laurence, STEPHAN G., TAWN E. J., VOISIN Pascale, WHITEHOUSE Caroline A.
Date de publication >
Several European laboratories have combined their research efforts to arrive at a consensus view on using fluorescence in situ hybridisation (FISH) for retrospective dosimetry. The aim of this review is to report these views and to highlight some areas where further work is needed. Translocations in the stable cells should be measured only in the cells that contain the full complement of the painted material. Two-way and one-way translocations should be combined with equal weight. The control level of translocations has a strong dependence on age, which has now been measured and the system has been calibrated. In conclusion, the technique works and a lifetime dose to the bone marrow from low-linear energy transfer radiation of 0.5 Gy above normal background levels can be measured for any individual. The main application is considered to provide an independent verification of lifetime doses to individuals who might form a part of an epidemiological study.