Characterization of potential ionising radiation biomarkers by a proteomics approach
Titre du congrès :IRPA 2006 2nd European IRPA Congress on Radiation Protection
Ville du congrès :Paris
Date du congrès :15/05/2006
Radio-induced lésions are tissue spécifie, hardly predictable, and can arise months or years later. The finding of prognostic biomarkers is of fundamental relevance for the settlement of therapeutic or préventive stratégies. Using two-dimensional gel electrophoresis and mass spectrometry, a proteomics study was applied to look for differentially expressed proteins, Le. potential biomarkers candidates, in mouse serums after a local irradiation of the dorsal skin. Our results clearly indicated that sérum protein content was dynamically modified after a local skin irradiation. A set of spécifie proteins were early down- or up-regulated and could turn out to be good candidates as diagnostic or prognostic biomarkers.