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Influence of chromatin condensation on the number of direct DSB damages induced by ions studied using a Monte Carlo code


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​Radiation Protection Dosimetry / Volume 161, issue 1-4, pages 469-473, mars 2014

Type de document > *Article de revue

Mots clés >

Unité de recherche > IRSN/PRP-HOM/SDE/LDRI, IRSN/PRP-HOM/SRBE/LDB

Auteurs > DOS SANTOS Morgane, CLAIRAND Isabelle, GRUEL Gaëtan, BARQUINERO Joan Francesc, INCERTI Sébastien, VILLAGRASA Carmen

Date de publication > 09/03/2014

Résumé

​The purpose of this work is to evaluate the influence of the chromatin condensation on the number of direct double-strand break (DSB) damages induced by ions. Two geometries of chromosome territories containing either condensed or decondensed chromatin were implemented as biological targets in the Geant4 Monte Carlo simulation code and proton and alpha irradiation was simulated using the Geant4-DNA processes. A DBSCAN algorithm was used in order to detect energy deposition clusters that could give rise to single-strand breaks or DSBs on the DNA molecule. The results of this study show an increase in the number and complexity of DNA DSBs in condensed chromatin when compared with decondensed chromatin.