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Immune system modifications induced in a mouse model of chronic exposure to 90Sr


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​Radiation Research / volume 185, issue 3, pages 267-284. mars 2016

Type de document > *Article de revue

Mots clés >

Unité de recherche > IRSN/PRP-HOM/SRBE/LRTOX

Auteurs > SYNHAEVE Nicholas, MUSILLI Stefania, STEFANI Johanna, NICOLAS Nour, DELISSEN Olivia, DUBLINEAU Isabelle, BERTHO Jean-Marc

Date de publication > 01/03/2016

Résumé

​Strontium 90 (90Sr) remains in the environment long after a major nuclear disaster occurs. As a result, populations living on contaminated land are potentially exposed to daily ingesting of low quantities of 90Sr. The potential long-term health effects of such chronic contamination are unknown. In this study, we used a mouse model to evaluate the effects of 90Sr ingestion on the immune system, the animals were chronically exposed to 90Sr in drinking water at a concentration of 20 kBq/l, for a daily ingestion of 80–100 Bq/day. This resulted in a reduced number of CD19+ B lymphocytes in the bone marrow and spleen in steady-state conditions. In contrast, the results from a vaccine experiment performed as a functional test of the immune system showed that in response to T-dependent antigens, there was a reduction in IgG specific to tetanus toxin (TT), a balanced Th1/Th2 response inducer antigen, but not to keyhole limpet hemocyanin (KLH), a strong Th2 response inducer antigen. This was accompanied by a reduction in Th1 cells in the spleen, consistent with the observed reduction in specific IgG concentration. The precise mechanisms by which 90Sr acts on the immune system remain to be elucidated. However, our results suggest that 90Sr ingestion may be responsible for some of the reported effects of internal contamination on the immune system in civilian populations exposed to the Chernobyl fallout.