The SARRP is also used to study the effects of low radiation doses (≤ 2 Gy). The consequences of this type of exposure on brain function and on the related pathophysiological mechanisms are studied through the development of several irradiation models on the facility (highly localized irradiation of certain cerebral sub-structures and of the whole head).
Lastly, the irradiator is used by the IRSN as part of the ROSIRIS program, the purpose of which is to better understand the causal relationship between the early effects and the delayed effects of ionizing radiation on the body. The type of initial radiation-induced cell damage depends on the way in which the energy of an ionizing particle is deposited within a cell, and therefore the physical characteristics of that particle. To analyze the damage, one of the research avenues consists of establishing links between biophysical modeling of early radiation-induced events and their later consequences on molecules and cells, by studying the distribution, signaling and repair of the initial DNA damage and restoration of the chromatin architecture according to the type of ionizing radiation.
The SARRP offers reliable and reproducible dosimetry, with currently (September 2017), around ten dosimetry protocols available for in vitro irradiation, for voltages between 40 and 220 kV and intensities of between 2.5 and 27 mA.
The experiments are conducted in accordance with the set procedures and animal testing ethics rules.