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Epidemiological study of workers exposed to the risk of uranium absorption

Irina GUSEVA-CANU, doctorate of University Pierre et Marie Curie, 255 p., defended on the 29th september 2008


This work is a pilot-study among nuclear fuel cycle workers potentially exposed to alpha radiation. Internal exposure from inhalation of uranium compounds during uranium conversion and enrichment operations was estimated at the AREVA NC Pierrelatte plant.
A plant specific semi-quantitative job exposure matrix (JEM) was elaborated for 2709 workers employed at this plant between 1960 and 2006. The JEM has permitted to estimate the exposure to uranium and 16 other categories of pollutants and to calculate individual cumulative exposure score. Numerous correlations were detected between uranium compounds exposure and exposure to other pollutants, such as asbestos, ceramic refractive fibers, TCE and so on. 1968-2005 mortality follow-up showed an increasing risk of mortality from pleural cancer, rectal cancer and lymphoma on the basis of national mortality rates.
Analyses of association between cancer mortality and uranium exposure suggested an increase in mortality due to lung cancer among workers exposed to slowly soluble uranium compounds derived from natural and reprocessed uranium. However these results are not statistically significant and based on a small number of observed deaths.
These results are concordant with previously reported results from other cohorts of workers potentially exposed to uranium. Experimental studies of biokinetic and action mechanism of slowly soluble uranium oxides bear the biological plausibility of the observed results.
Influence of bias was reduced by taking into account of possible confoundings including coexposure to other carcinogenic pollutants and tobacco consumption in the study.
Nevertheless, at this stage statistical power of analyses is too limited to obtain more conclusive results.
This pilot study shows the interest and feasibility of an epidemiological investigation among workers at risk of internal exposure to uranium and other alpha emitters at the national level. It demonstrates the importance of exposure assessment for all carcinogenic pollutants likely to be associated with uranium exposure. Accounting for these associated exposures in analyses is also important especially for cancer outcomes. In a wider context, this work provides additional data on a possible carcinogenic effect of protracted uranium exposure and alpha radiation in humans.

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Margot Tirmarche, thesis supervisor

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