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Research

Theses viva

Effect of low dose ionising radiation in atherosclerosis: implication of adaptive immunomodulatory mechanisms


Nicolas Rey will defend his thesis

on Friday 5th February 2021 at 2:00 pm

at the auditorium of IRSN, building 01

31 Avenue de la Division Leclerc
92260 Fontenay-aux-Roses

France





Abstract

The purpose of this thesis is to study the effects of low doses of ionizing γ radiation in atherosclerosis, an inflammatory disease of the walls of large and medium-gauge vessels. Studies have shown that exposure to low doses can improve the disease by reducing inflammation, so we wanted to understand how ionizing radiation modulates the immune system.

To do this, we used mouse models "mimicking" atherosclerosis, which we irradiated at low doses. We noticed that the ionizing radiation mainly affected monocytes and macrophages, cells of the innate immunity that are very important for the development of the disease. Moreover, these effects were more important at the highest dose where we observed a significant reduction in inflammation. Finally, we also showed that the effects of low doses could persist long after irradiation.



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