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Experimental determination of the solubility of industrial UF4 particulates



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AUTHORS : Chazel, V.; Houpert, P.; Paquet, F.; Ansoborlo, E.; Henge-Napoli, M.H Radiation Prot. Dos. 2000, vol 92 n° 4, 289-294

Type de document > *Article de revue

Mots clés > radiotoxicologie, uranium

Unité de recherche > Laboratoire d'études appliquées de radiotoxicologie (LEAR)

Auteurs > HOUPERT Pascale, PAQUET François

Date de publication > 01/01/2000


The chemical solubility in cell culture medium and in Gamble's solution and the biokinetic behaviour on rats of an industriel UF4 compound have been studied in order to predict experimentally absorption parameters after inhalation and to provide data for interpreting bioassay data. According to these results, this compound has been found to have an intermediate type of obsorption between Types F and M as designated by ICRP for the human respiratory tract. A dose coefficient of 1.4µSv/Bq has been calculated for an inhaled aerosol with an AMAD of 5.1 µm (sigma(g)=2.5), which corresponded to the mean value encountered at the fluorination workplace. Predictive urinary and faecal excretion and lung retention curves have also been deduced to calculate the incorporated activity and the received dose in case of an inhalation of UF4 by workers.