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Phosphate/UO2 interaction during in vitro dissolution of inhalable particles in a medium simulating the phagolysosomal compartment



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S. Matton, I. Bailly, P. Massiot, E. Ansoborlo, and P. Fritsch Radiat. Prot. Dosim. 1998, 79(1-4), pp 49-51 WORKSHOP ON INTAKES OF RADIONUCLIDES: Occupational and Public Exposure - Proceedings of a Workshop held in Avignon, France. September 15-18 1997

Type de document > *Article de revue, *Congrès/colloque

Mots clés > radiotoxicologie, uranium

Unité de recherche > Laboratoire d'études appliquées de radiotoxicologie (LEAR)

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Date de publication >  


Qualitative and quantitative methods have been developed to relate phosphate/UO2 interactions and U dissolution, in vitro, in a medium containing 0 or 10 mM phosphate concentrations at pH 5. This was performed by Energy Dispersive X ray Spectrometry (EDS) at 200 kV on entire particles and by fluorimetric measurement. The U dissolution rate was larger in a medium without phosphate than in a medium containing 10 mM phosphate. During the first day, the initial U dissolution involved 80.55% and 91.13% of the powder in media with and without phosphate respectively. From 5 to 15 d after beginning the assay, the dissolution half-times were longer than 92 d and 22 d for media with and without phosphate. EDS analyses have shown a constant P/U X ray intensity ratio for reference U2O(PO4)2 for the same range of particle diameter. A gradual increase of this ratio was measured for UO2 incubated in a 10 mM phosphate medium throughout the experiment.