IRSN, Institut de radioprotection et de sûreté nucléaire

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Research Units

Experimental Radiotoxicology and Radiobiology Laboratory (LRTOX)

​Last update on November 2019



Context and research themes


The mission of LRTOX is to perform all types of experimental studies enabling acquisition of the basic data necessary to assess the levels and consequences of incorporation of radionuclides.

In particular, it coordinates the “health” input to the ENVIRHOM project, the objective of which is to describe the phenomenon of chronic accumulation of nuclides and to determine their effects on organisms.



Research topics

The main skills of the laboratory are:

  • The study of physical chemical characteristics of industrial compounds at workstations,
  • The biokinetic study of radionuclides after incorporation by ingestion, inhalation or injury,
  • Determination of the biological effects resulting from accumulation of incorporated radionuclides,
  • Determination at molecular level of the fixation and retention mechanisms for radionuclides in organisms.



Research team


Dmitry Klokov, head of laboratory

Laurence Roy, researcher

Jean-Marc Bertho, researcher

David Cohen, researcher

Christelle Durand, biology researcher

Teni Ebrahimian Chiusa, researcher

Christelle Elie, technician

Céline Gloaguen, biology technician

Stéphane Grison, research engineer

Christelle Ibanez, researcher

Dimitri Kereselidze, analysis technician

Philippe Lestaevel, researcher

Alice Bontemps, PhD student (2016-2019)
Léo Mace, PhD student (2018-2021)
Nicolas Rey, PhD student (2017-2020)
Céline Serrano, PhD student (2017-2020)



Facilities and techniques


  • Rodent house in controlled zone
  • Atmospheric sampling apparatus
  • Inhalation enclosures
  • Scanning and transmission electron microscopes
  • X-ray diffraction
  • Autoradiography systems
  • HPLC, EC, ultracentrifuge
  • Alpha, beta, gamma radio-chemistry

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Chercheur en radiotoxicologie  Crédits : Thomas Gogny/IRSN


Dmitry Klokov, head of laboratory


Experimental Radiotoxicology and Radiobiology Laboratory (LRTOX)
BP 17
92260 Fontenay-aux-Roses


By Phone: +33 (0)1 58 35 72 12


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