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Enhancing Nuclear Safety


Research

Research programmes

Alpha Risk programme's work packages

7 Work packages (WP) have been defined for the Alpha Risk programme: 4 are dedicated to epidemilogical studies, the 5th focuses on calculation of organ doses, the 6th aims to the integration of results and the 7th is in charge of the general management.

Epidemiological studies

WP1: Cohorts of uranium miners

Data
. Cohorts of uranium miners in France, the Czech Republic and Germany
. Nested case-control studies
. Reconstruction of multiple exposures (radon, gamma exposure, uranium dust)
Methodology
. Dosimetric models
. Parametric statistical methods and biologically based modelling approaches
. Consideration of measurements errors and uncertainty
Objectives
. Time-modifier of the radon-lung cancer risk relationship
. Risk associated to tobacco, radon and other radiation sources in the mines
. Risk of cancers other than lung
. Non cancer mortality risk

WP2: Indoor radon studies

Data
.Case control studies in europe, in north america and China
. Detailed information on smoking history
Methodology
. Case control studies approach
. Collaborative analysis of worldwide data on indoor radon
. Statistical methodology able to adjust for random uncertainties
Objectives
. To quantify lung cancer risk associated to indoor radon exposure
. To provide a direct evidence of radon risk among non smokers
. To consider random uncertainties
. To develop a risk assessment methodology for different specific reference populations

WP3: Nested case-control studies among nuclear workers

Background
. International study of cancer risk among radiation workers in the nuclear industry
Objectives
. Lung cancer mortality risk for exposure to specific radionuclides
. Joint effects of internal and external radiation exposure
. Feasibility of a leukaemia study
Methodology
. Nested case-control studies among nuclear workers in Europe
. Reconstruction of internal and external exposures, smoking habits and exposure to other occupational carcinogens
. Consideration of measurement errors and uncertainty
Population
. Over 50,000 workers with potential internal exposure

WP4: Cohorts of nuclear workers with internal exposure

Background
. BNFL (British Nuclear Fuels) workers cohort study
Objectives
. Feasibility of a joint statistical analysis of the french and UK nuclear workers
Methodology
. Cohort studies
. Study protocols and agreements for a future analysis
. Common internal dose protocol and provision of organ dose estimates
. Definition of available data for a joint nuclear worker cohort study
Population
. About 15,000 workers with potential internal exposure

Dosimetric expertise

WP5: Organ dose

Objectives
. To calculate estimates of individual doses to specific target organs
. Dose associated to multiple exposures
. Application to european uranium miners data
Methodology
. Comparaison of different modelling approaches
. Quantification of doses uncertainties
Expected results
. Quantification of dose-risk relationships
. Insight into the alpha dose equivalence

Risk assessment

WP6: Integration of results

Objectives
. To integrate results from other WPs, with a particular focus on radon
. To derive estimates of lifetime cancer risks associated to chronic exposures
Methodology
. Comparison of different models and studies
. Definition of standardised scenarios
. Impact of measurement errors



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