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Effect of external irradiation on the gastrointestinal absorption of uranium and neptunium in rats

Houpert P, Paquet F, Dublineau-Naud I Int J Radiat Biol 2001 Mar;77(3):383-8

Summary

PURPOSE: The gastrointestinal absorption and systemic distribution of uranium and neptunium were determined after external gamma irradiation. MATERIALS AND METHODS: Rats were exposed to a single whole-body dose of gamma radiation (6Gy; 0.75Gy.min(-1)). Three days after irradiation they were orally and/or intravenously contaminated with 100 microg.kg(-1) uranium or 3kBq.kg(-1) neptunium. The gastrointestinal absorption and organ distribution of both radionuclides were measured 6 days after irradiation. RESULTS: External irradiation increased the intestinal transit time of uranium and neptunium but had no effect on their gastrointestinal absorption. The average fractional absorption was determined to be 0.93 and 0.98% (uranium) and 4.7 and 4.8% (neptunium) for the irradiated and non-irradiated rats respectively. The excretion of uranium and neptunium was not affected by the irradiation. CONCLUSION: A 6 Gy whole-body irradiation (gamma; 0.75Gy.min(-1)) did not affect the absorption of uranium and neptunium after oral intake.

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