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Human mesenchymal stem cells home to the skin and stop the necrotic evolution of the radiation-induced lesions: A xenogenic transplant model for the treatment of the cutaneous radiation syndrome.


Congress title :ISSCR
Congress town :Queerns 
Congress date :18/06/2007

Document type > *Congrès/colloque

Keywords > healing, Mesenchymal Stem Cell (MSC), skin

Research Unit > IRSN/DRPH/SRBE/LTCRA

Authors > CHAPEL Alain, GOURMELON Patrick, MOUISEDDINE Moubarak, SACHE Amandine

Publication Date > 20/06/2007

Summary

Skin complications play an important role in radiation accidents, in radiotherapy and radio-oncology. Several therapeutic strategies of severe radiation induced damages to the skin (including surgical procedures) have been used with some success. Stem cell therapy may be a promising therapeutic approach to reduce radiation-induced skin tissue damages. It has been suggested that human Mesenchymal Stem Cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC in order to limit radiation-induced skin lesions. Immunodeficient NOD/SCID mice were locally irradiated to the leg (30 Gy, dose rate 2.7 Gy/mn) using a 60Co source in order to induce a severe skin lesion. Cultured bone marrow hMSC were delivered intravenously to the mice. The irradiated skin samples were studied for the presence of the human cells, the severity of the lesions and the healing process. Macroscopic analysis and histology results showed that the lesions were evolving to a less severe degree of radiation dermatitis following hMSC transplant when compared to irradiated non-transplanted controls. Clinical scores for the studied skin parameters of treated mice were significantly improved. A faster healing was observed when compared to untreated mouse. Immunohistology and Polymerase Chain reaction (PCR) analysis provided evidence that the human cells were found in the irradiated area. These results suggest a possible use of hMSC for the treatment of the early phase of the cutaneous radiation syndrome. A successful transplant of stem cells and subsequent reduction in radiation-induced complication may open the road to completely new strategies in cutaneous radiation syndrome therapy

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