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The gastrointestinal absorption of 63Ni and 95Nb in adult and neonatal rats: effect of the chemical form administered


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F. Paquet, P. Houpert, M. Verry, G. Grillon, J.D. Harrison and H. Métivier Radiat. Prot. Dosim. 1998, 79(1-4), pp 191-195 WORKSHOP ON INTAKES OF RADIONUCLIDES: Occupational and Public Exposure - Proceedings of a Workshop held in Avignon, France. September 15-18 1997

Type de document > *Article de revue, *Congrès/colloque

Mots clés > radiotoxicologie, nickel, niobium

Unité de recherche > Laboratoire d'études appliquées de radiotoxicologie (LEAR)

Auteurs > HOUPERT Pascale, PAQUET François

Date de publication > 01/01/1998

Résumé

The gastrointestinal absorption of 63Ni and 95Nb has been determined in adult and neonatal rats after administration as various chemical forms. For 63Ni, f1 was determined as (4.3 ± 1.4) x 10-2, (5.1 ± 2.1) x 10-2 and (3.3 ± 1.5) x 10-2, for the citrate, oxalate and chloride forms, respectively. For 95Nb, the corresponding f1 values were (1.25 ± 0.37) x 10-2, (0.37 ± 0.15) x 10-2 and (0.24 ± 0.07) x 10-2, respectively. When radionuclides were administered to 1 day old animals, the retention increased by factors of up to 40 and 200 for 63Ni-chloride and 95Nb-oxalate, respectively. All these results are discussed with respect to the ICRP recommendations.