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Ionizing radiation enhances IL-6 and IL-8 production by human endothelial cells.


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Van der meeren A., Bertho J-M, Vandamme M., Gaugler M-H.
Mediators of inflammation - Volume 6, Issue 3, 1997, Pages 185-193  

Résumé

Irradiation exposure is known to induce an inflammatory reaction. Endothelial cells play a crucial role both in the inflammatory process and in radiation damage. Therefore, supernatants and cell lysates of Co-irradiated human umbilical vein endothelial cells (HUVEC) have been assessed for the presence of pro-inflammatory cytokines. After irradiation, interleukin (IL)-1a, IL-1ß and tumor necrosis factor (TNF)-a remained undetectable in both cell supernatants and cell lysates. However, a dose-dependent increase in the production of IL-6 and IL-8 has been demonstrated up to 6 days after exposure. These data indicate that the pro-inflammatory cytokines IL-6 and IL-8 may be involved in the inflammatory response of vascular endothelium induced by exposure to ionizing radiation.