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Kinetics of plasma FLT3 ligand concentration in hematopoietic stem cell transplated patients


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M. Prat, J. Frick, J.P. Laporte, D. Thierry, N.C. Gorin et J.M. Bertho

Leukemia & Lymphoma, 2006, 47 (1) : 77-80

Type de document > *Article de revue

Mots clés > radioprotection, bioindicateur, Flt3-ligand, moelle osseuse

Unité de recherche > IRSN/DRPH/SRBE/LTCRA

Auteurs > BERTHO Jean-Marc, FRICK Johanna, THIERRY Dominique

Date de publication > 01/01/2006

Résumé

The aim of this work was to follow-up variations in plasma Flt3 ligand (FL) concentration after hematopoietic stem cell transplantation (HSCT) and to compare the influence of conditioning regimens on variations in FL concentration. Ten patients undergoing conditioning regimen including BEAM, cyclophosphamide (Cy) + total body irradiation (TBI) or Cy + anti-thymocyte globulins (ATG) and followed by hematopoietic stem cell transplantation were studied. Plasma FL concentrations, white blood cells (WBC) expression of both FL mRNA and the membrane-bound form of FL (mFL) were carried out at different times post treatment. Results indicated that plasma FL concentration increased rapidly after conditioning regimen in all patients, in correlation with the decrease in number of WBC. Area under the curve of FL according to the time was directly correlated with the duration of pancytopenia, except when ATG was included in the conditioning regimen. Although the number of patients was limited in this study, the comparison of ATG-treated patients and other patients suggests that plasma FL concentration is regulated by a complex mechanism involving in part circulating blood cells.