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Ex vivo uranium decontamination efficiency on wounded skin and in vitro skin toxicity of a calixarene-loaded nanoemulsion


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​Journal of Pharmaceutical Sciences / Volume 104, Issue 6, pages 2008-2017, juin 2015

Type de document > *Article de revue

Mots clés >

Unité de recherche > IRSN/PRP-HOM/SDI/LRC

Auteurs > GRIVES Sophie, PHAN Guillaume, MORAT Guillaume, SUHARD David, REBIERE François, FATTAL Elias

Date de publication > 04/04/2015

Résumé

​The present work aims at studying the decontamination efficacy of a calixarene-loaded nanoemulsion on two ex vivo wounded skin models mimicking superficial stings or cuts contaminated with uranium, and on a third model using excoriation. The decontaminating formulation was compared with the currently used radio-decontaminating soapy water (Trait rouge®) treatment. Moreover, to assess skin damage potentially induced by the undiluted nanoemulsion, in vitro toxicity studies were conducted on an in vitro reconstructed human epidermis, coupled with three different toxicity tests [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide, lactate dehydrogenase, and interleukin-1-α]. This work demonstrated not only a significant decontamination activity of the calixarene nanoemulsion on wounded skin, ranging from 92% to 94% of the applied uranium solution according to the ex vivo model used, but also the absence of side effects of this promising treatment.

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