IRSN researcher wins best poster award in radiobiology
Olivier Guipaud received a best poster award in radiobiology at the ENLIGHT (European Network for Light ion Hadron Therapy) annual meeting, held on July 1–3 in Caen.
The poster, entitled Molecular profile of human primary vascular endothelial cells exposed to high doses of carbon ions in comparison to photon irradiations, focused on work carried out by the Radiobiology of Medical Exposure Laboratory (LRMED)* under the France Hadron platform and IRSN’s ROSIRIS program.
The study compared the cellular and molecular effects produced in vitro by exposure to carbon ions—with irradiation performed at the GANIL heavy ion accelerator in Caen—to those produced by exposure to photons traditionally used in radiotherapy (with irradiation performed at IRSN using a LINAC). More generally, the work aims to develop ways to assess the impact of radiation or a specific irradiation method on vascular endothelial cell function. The irradiation of these cells—in both normal and cancerous tissue—causes them to malfunction, resulting in early and late tissue damage. The study is also helpful in reviewing the concept of relative biological effectiveness (RBE), a radiobiology tool used to assess the risks of new radiotherapy techniques (“flash” radiotherapy, hypofractionation, hadron therapy, etc.) and help adapt the associated radiation protection guidelines.
* Part of the Department for Research in Radiobiology and Regenerative Medicine (Seramed) – IRSN Environment and Health Division
Find out more about the ENLIGHT annual meeting
Find out more about LRMED
Event - AwardThe IRSN recognized at the last SFRP conference
The French Radioprotection Society (SFRP) conference was held from June 18-20 in La Rochelle and was a great success! The IRSN played a key role in the event by presiding over nearly half of the sessions and co-leading four of the nine tutorials. Two researchers from the institute were presented with an award, specifically the first and second place awards for the Henri Jammet Prize.
Every two years, the SFRP conference provides all professionals who are involved in the protection against ionizing and non-ionizing radiation in the fields of research, medicine, manufacturing, and nuclear electricity with an opportunity to present their latest work and views.
Annaïg Bertho, a doctoral student at the IRSN's LRMED1
, won the Henri Jammet Prize for her thesis on pulmonary lesions resulting from stereotactic irradiation. Her research combines preclinical modeling with the acquisition of radiobiological data using various types of pulmonary cells and will contribute to science's understanding of the risks and effects of stereotactic irradiation on healthy tissue. As the winner of the award, Annaïg Bertho will be invited by the SFRP to attend the international IRPA conference, which will take place in Seoul, South Korea in May 2020. There, she will take part in the "Young Professional Awards" and follow in the footsteps of Nadia Bendabdallah
, an IRSN colleague who won the previous edition of the awards. The second place award of the Henri Jammet Prize was presented to Tiffany Beaumont, a researcher at the LAMIV2 who also recently won the Pheniics Award
for her presentation on the contribution of 3D printing to the production of calibration phantoms designed for personalized internal dosimetry measurements.
Every two years, the Henri Jammet Prize recognizes young professionals or scientists for the quality and originality of their radioprotection research. This year, the jury included:
- Bernard Le Guen, President of the SFRP and the jury (EDF);
- Florence Ménétrier, representative of the "Radioprotection" Journal Commission (CEA);
- Sylvain Papin, representative of the Young SFRP Member Club (SPRA);
- Didier Gay, SFRP board member and president of the program committee (IRSN);
- Pierre-Yves Hémidy, member of the SFRP, environment section (EDF);
- Martine Souques, member of the SFRP, non-ionizing radiation section (EDF);
- Valérie Chambrette, Director of the SFRP.
The SFRP also designated Yann Billarand as its newly elected president during the La Rochelle conference. Yann Billarand is a manager under the IRSN Environment Director within the Health and Environment Division. He will take office during the next conference, which is scheduled to take place in Dijon in 2021.1. Medical Exposure Radiobiology Laboratory, Health and Environment Division2. In Vivo Measurement Laboratory, Health and Environment Division
Find out more about Annaïg Bertho thesis
Find out more about Tiffany Beaumont work
Find out more about SFRP
IRSN doctoral student wins a Young Scientist Award
Lapière, a doctoral student at the Radiobiology of Medical Exposure
Laboratory (LRMed)*, won the third Young Scientist Award during the
13th International Probiotic
Congress (IPC) held from June 17-20 in Prague, Czech
Republic. This was the fourth award presented to the doctoral student
since the beginning of her thesis.
presentation focused on her thesis research and was entitled,
"Faecalibacterium prausnitzii Treatment Reduces
Radiation-Induced Colorectal Injury: Application to the Management of
Pelvic Radiotherapy Complications". Her work focus on the
effects of a probiotic, Faecalibacterium prausnitzii, on
delayed onset colonic lesions, which can occur up to 10 years after
pelvic radiation therapy. This research, carried out in collaboration
with INRA (French National Agronomic Research Institute) aims to
assess the efficacy of this probiotic, which is administered
preventively before radiation therapy, to reduce lesions in healthy
tissue. Its effectiveness has already been proven in pre-clinical
studies, where it was used to treat other inflammatory pathologies of
the colon, such as Crohn's disease.
Lapière accepts her award. © IPC
Young Scientist Awards, which are presented during the IPC, recognize
young scientists at the start of their careers who are conducting
excellent work in the fields of basic or applied research regarding
probiotics and prebiotics.
the Health and Environment Division (PSE) of the IRSN
Find out more about IPC
The 19th issue of Aktis, IRSN’s scientific newsletter, is available
The nineteenth English-language issue of Aktis, the quarterly newsletter on IRSN’s research, is available on a HTML and PDF package. Aktis is published only in a digital version and available in HTML or text format for e-mail, RSS and pageflip PDF.
In this issue, focus on whether the vascular endothelium is a key target for improving radiotherapy treatments. Aktis n°19 also treats of Fukushima Daiichi decommissiong and also of links between radiation-induced effects, heredity and epigenetics. As well, it deals with nuclear safety regulation from 1945 to the present.
The subscription for the English and French versions is complimentary. To read this issue or subscribe, go to
Read the pageflip PDF
Read the HTML
Reduction of the side effects of aerodigestive tract radiotherapy on bone tissue. Launch of the IXBONE project
The IRSN has launched its IXBONE project, which aims to develop a new cell therapy strategy to limit induced side effects on bone tissue following radiation therapy used in the treatment of cancers of the upper respiratory and digestive tracts. The project receives funding from the ANR (Agence nationale de la recherche) obtained under the 2018 call for projects PRCE "Projet de recherche collaborative-Entreprise".
The aim of the IXBONE project is to develop a protocol for a cellular and matrix therapy based on the use of mesenchymal stromal cells (MSCs) in a biomaterial matrix, to help regenerate bone tissue damaged by radiation therapy in ENT. This four-year project is coordinated by the RmeS laboratory (INSERM U1229, University of Nantes-Oniris), in partnership with the Laboratory of radiobiology of medical exposures (LRMed) of the IRSN and the company OTR3.
The fourth most common cancer in humans in France, squamous cell carcinoma accounts for 90% of cancers in ENT. When treated with radiotherapy, 5% of patients develop a serious side effect called mandibular osteoradionecrosis (ORN), a necrosis of the jaw that can lead to fractures and serious disorders of swallowing and phonation (production of the sounds of spoken language).
The principle of the IXBONE project consists of local injections of bone marrow MSCs, protected by a hydrogel matrix (hydroxypropylmethyl-cellulose – HPMC) and associated with synthetic molecules, RGTAs (Regenerating Agents), which increase the therapeutic efficacy of MSCs. This principle has already been used successfully in the development of a new therapeutic strategy aimed at relieving the side effects of abdominal and pelvic radiotherapy (the
ANTHOS project). MSCs are known to act effectively in the regeneration of tissues and bones as a result of the activity of certain proteins they release.
Thanks to the development of a biomaterial intended to serve as a matrix for the MSCs as they are injected, the IXBONE project will eventually propose an effective therapeutic strategy for patients developing ORN, with the aim of a future clinical trial involving human patients suffering from ORN.
Find out more about the IXBONE project
Find out more about the Agence nationale de la recherche (ANR)
Find out more about the involved IRSN laboratory
IRSN strengthens its commitment towards open science
IRSN's scientific publications will now be automatically uploaded to
French national open archive HAL
articles en ligne),
was created in 2001 by the CNRS's Center for Direct Scientific
Communication (CCSD). Anyone can now access the IRSN's digital
research articles for free in accordance with the distribution rights
specified by the publisher.
the past several years, the IRSN was been working to promote open
access, particularly through the HAL platform. The institute
develop the platform in 2013. Using a new service that automatically
publishes its scientific articles on HAL, the IRSN is strengthening
this partnership. This decision also helps reach the goals regarding
the publication of scientific knowledge and expertise sharing
expressed in the
National Plan for Open Science
an initiative launched by Science Europe named
The aim of both of these plans is to ensure that 100% of all new
French scientific publications are made available on an open-access
basis. The IRSN is also planning on publishing all the scientific
articles written by the institute since its founding in 2002 on the
HAL platform by 2021.
Niel, Director General of the IRSN, inaugurates a new service that
will publish all IRSN publications on HAL. Audrey Legendre, Knowledge
Engineering Manager, stands at his side. © Sandrine Marano/IRSN
making its scientific publications available in this way, the IRSN
helps to share and distribute research findings, thereby increasing
the visibility of French research. The institute supports knowledge
sharing in the radiology and nuclear science industries.
IRSN receives a number of benefits by granting free access to its
publications, including limitless archival storage on HAL, increased
visibility of its research (complete article and full citation list),
accessibility (digital and free), and distribution in accordance with
the copyright limitations set by publishers.
The S Plan, an initiative launched by Science Europe to promote open
access to scientific publications, is supported by the European
Research Council and the research funding agencies of 12 European
Go to HAL portal of the IRSN