The Experimental Radiotoxicology and Radiobiology Laboratory (LRTOX) is located on sites at Pierrelatte and Fontenay-aux-Roses. It comprises 24 personnel including 7 researchers (physical chemists, biologists and veterinarians), several student doctorands and post-doctorates.
Context and research themes
The mission of LRTOX is to perform all types of experimental studies enabling acquisition of the basic data necessary to assess the levels and consequences of incorporation of radionuclides.
In particular, it coordinates the “health” input to the ENVIRHOM project, the objective of which is to describe the phenomenon of chronic accumulation of nuclides and to determine their effects on organisms.
The main skills of the laboratory are:
- The study of physical chemical characteristics of industrial compounds at workstations,
- The biokinetic study of radionuclides after incorporation by ingestion, inhalation or injury,
- Determination of the biological effects resulting from accumulation of incorporated radionuclides,
- Determination at molecular level of the fixation and retention mechanisms for radionuclides in organisms.
Karine Tack, head of laboratory
Jean-Marc Bertho, researcher
David Cohen, researcher
Christelle Durand, biology researcher
Teni Ebrahimian Chiusa, researcher
Christelle Elie, technician
Céline Gloaguen, biology technician
Stéphane Grison, research engineer
Yann Gueguen, researcher
Christelle Ibanez, researcher
Dimitri Kereselidze, analysis technician
Audrey Legendre, researcher
Philippe Lestaevel, researcher
Maâmar Souidi, researcherAlice Bontemps, PhD student (2016-2019)
Dalila Lebsir, PhD student (2015-2018)
Facilities and techniques
- Rodent house in controlled zone
- Atmospheric sampling apparatus
- Inhalation enclosures
- Scanning and transmission electron microscopes
- X-ray diffraction
- Autoradiography systems
- HPLC, EC, ultracentrifuge
- Alpha, beta, gamma radio-chemistry