Operations of decommissioning and decontamination in nuclear facilities require setting up depressurized enclosures around contaminated areas in order to prevent leakage of radioactive materials, to the surrounding environment. Air passes through openings which generates a directional airflow ensuring the aerodynamic containment of hazardous material inside the enclosure. Due to operating activities inside or outside the enclosure, the directional flow might be disturbed. Consequently, local and unsteady backflows may occur at the opening leading to the outward transport of contamination. The current study is focused on airflow dynamics through small openings, such as rectangular slits where the initial inflow stream is turbulent. The main purposes of this work are to identify the required aerodynamic conditions likely to generate unsteady flow inversions at the studied opening and also to verify the ability of CFD simulations to predict this type of flow by using URANS and LES approaches. Results have shown that an additional flow, such as a turbulent jet or a wake in competition with inward flow, is the main cause leading to the leakage at the opening. Experiments, using gas tracer detection techniques, are conducted in order to quantify outflow leakage in the near field of the opening under different aerodynamic configurations and openings characteristics. A laser tomography technique is also implemented to visualize the external leakage airflow in the middle plane of the opening. CFD simulations have shown that a qualitative description of instantaneous leakage flow patterns at the opening can be achieved. This is characterized by the occurrence of local coherent structures transporting passive tracer outwards. Moreover, velocities obtained from CFD results (Large Eddy Simulations) are compared to those obtained from experimental measurements.