Speciation and Internai dosimetry: from chemical species to dosimetric models.
F. PAQUET, S. FRELON, G. COTE, C. MADIC Radioprotection 2004 DOI: 10.1051/radiopro:2004005 Vol. 39, n° 3, pages 341 à 354
Speciation studies refer to the distribution of species in a particular sample or matrix. There studies are necessary to improve the description, understanding and prediction of trace element kinetics and toxicity. In case of internai contamination with radionuclides, speciation studies could help to improve both the biokinetic and dosimetric models for radionuclides. There are different methods to approach the speciation of radionuclide in a biological system, depending on the degree of accuracy needed and the level of uncertainties accepted. Among them, computer modelling and experimental determination are complementary approaches. This paper describes what is known about speciation of actinides in blood, GI-tract, liver and skeleton and of their consequences in terms of internai dosimetry. The conclusion is that such studies provide very valuable data and should be targeted in the future on some specific tissues and biomolecules.