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In vitro experiments to determine the mechanisms by which chelators remove neptunium and uranium from the body



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F. Paquet, B. Ramounet, M.H. Hengé-Napoli, H. Métivier and P. Gourmelon Radiat. Prot. Dosim. 1998, 79(1-4), pp 467-470 WORKSHOP ON INTAKES OF RADIONUCLIDES: Occupational and Public Exposure - Proceedings of a Workshop held in Avignon, France. September 15-18 1997


In vitro experiments have been performed to elucidate the mechanisms by which chelators remove the radionuclides from the body. In the first part of this large-scale study, experiments have been performed to understand why the recommended chelators, DTPA and NaHCO3, are ineffective for neptunium and uranium decorporation. Blood, liver and bone were isolated either after in vivo or in vitro contamination and the effect of various concentrations of DTPA or NaHCO3 were tested for the dissociation of the biological complexes. The results showed that DTPA and NaHCO3 were ineffective both in preventing the organ deposition of the neptunium and uranium and in removing them from the target organs. Other studies using sodium citrate of 3,4,3-Li-HOPO showed better efficiency than that observed with the recommended chelators.