Modulation of brain inflammation during rabies infection by immunosuppressive treatments : ionising radiation, cyclosporine and cyclophosphamide
C.Marquette, P.Weber, P.Gourmelon, H.Tsiang, P-E Ceccaldi
Recent Res. Devel. Virol., 1 (1999) ; 735-751
Rabies virus is a highly neurotropic agent which invades the central nervous system (CNS) via the axonal transport. The infection is accompanied by a weak cytopathic effect but induces severe neural dysfunctions, that generally lead to death. However, the mechanisms that underly rabies pathogenesis are still poorly understood. One of the main features of rabies pathogenesis to be investigated was the central inflammatory reaction and its role in the neural and immune dysfunctions observed during rabies infection. Thus, the present paper will focus on the central nervous systern (CNS) inflammation process that follows rabies virus infection, using a mouse model of infection with fixed pathogenic or non-pathogenic rabies virus strains, with emphasis on the effect of different immunosuppressive agents on the course of rabies virus infection.
This work was done in collaboration with Institut Pasteur (Paris).