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The lipid atherogenic risk markers can be more favorably influenced by the cis9, trans 11-octadecadienoate isomer than a conjugated linoleic acid mixture or fish oil in hamsters.



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Karine Valeille, Daniel Gripois, Marie-France Blouquit, Maamar Souidi, Michel Riottot, Jean-Christophe Bouthegourd, Colette Sérougne, Jean-Charles Martin, British journal of nutrition, 2004, 91, 191-199.

Type de document > *Article de revue

Mots clés > athérosclérose, cholestérol, lipides

Unité de recherche > IRSN/DRPH/SRBE/LRTOX

Auteurs > SOUIDI Maâmar

Date de publication > 01/02/2004


  Our goal was to compare the efficiency of conjugated linoleic acids (CLA) and fish oil in modulating atherogenic risk markers. Adult male Hamsters were assigned for 8 weeks to a cholesterol-rich diet (0.06g/100g), augmented with either 0.5g/100g  of the cis9,trans11-CLA isomer, 1.2g/100g of a CLA mixture (CLA mix), 1.2g/100g of fish oil, or 1.2g/100g fish oil and 1.2g/100g of CLAmix. The plasma cholesterol status was improved only with the cis9,trans11-CLA (HDL-C and HDL-C/LDL-C ratio, P < 0.05) but was only border to significance for CLAmix (P =0.06 for HDL-C/LDL-C ratio), with an increase (33–40%) in the liver lipoprotein receptors (SR-BI and LDL-r) and binding protein (HB2) (P < 0.05). A 100% pigment gallstones incidence and a slight insulin resistance (HOMA index) were observed in the CLAmix fed-hamsters (P –0.031). In comparison, fish oil feeding alone improved merely the SR-BI and HB2 liver status and feces sterol output. For most of our observations, the concomitant intake of fish oil and CLAmix gave dominant effects that are exclusive, and specific to one or the other oil. In conclusion, part of the beneficial effects of CLA in this study can be ascribed to the cis9,trans11-isomer, and these did not generally overlap with those of fish oil. Additionnally, the CLAmix-effects are clearly impacted by the marine (n-3) fatty acids.